姚昌林

姚昌林 副教授

Email：cyao1992@ldu.edu.cn

教育经历：

2015.09-2021.06 山东大学 晶体材料研究所 材料学 工学博士

2018.10-2020.10 美国威斯康辛麦迪逊分校  访问学者  

2011.09-2015.06 济南大学 材料科学与工程学院 学士

工作经历：

2025.03-至今：鲁东大学集成电路学院

2021.12-2025.03：鲁东大学物理与光电工程学院

研究领域：

有机晶体的成核与生长机制

小分子药物晶体结构的主动设计及调控

药物分子晶体结构与性质研究

承担研究课题：

国家自然科学基金青年科学基金项目C类 (52502005)，2026.01-2028.12，主持，在研

山东省自然基金青年项目（ZR2023QB252），2024.01-2026.12，主持，在研

鲁东大学人才引进项目，2021.12-2026.12，主持，在研

山东省大学生创新创业项目 (2025, 2026)

学术论文：

相关研究成果发表在J. Am. Chem. Soc, J. Phys. Chem. Lett., ACS Appl. Mater. Interfaces, Cryst. Growth Des, CrystEngComm, J. Pharm. Sci.等晶体主流期刊(ORCID: https://orcid.org/0000-0002-8692-5842)，以第一作者或通讯作者发表论文及专利如下：

(1) Changlin Yao*; Yanliang Zhao, Yao Zhang, Huimin Li, Peizuo Han, Kangning Sun, Lei Wang*, Unraveling the Mystery of Polymorphic Selection in the Melt Crystallization of Piroxicam, Journal of Molecular Structure (2026), https://doi.org/10.1016/j.molstruc.2026.145244

(2) Peizhuo Han, Lei Wang*, Huimin Li, Changlin Yao*, Yaqian Qu, Xu Zhang, Hanlin Zhao, Yaqi Ren, Bozhang Li, Lufeng Xu, Weiguo Song, Xutang Tao, The New Cocrystal of Molnupiravir-Caprolactam Discovered by Melt Crystallization with Improved Tableting Properties. International Journal of Pharmaceutics, 2025: 125661. https://doi.org/10.1016/j.ijpharm.2025.125661

(3) Wenhui Meng, Haojie Sui, Zan Li, Xinjing Chen, Yongjia Li, Shufang Zhang*, Hai Zhong, Qi Zhang, Changlin Yao*, Dynamic self-regulating interfaces enable crystallization control and lead sequestration in perovskite photovoltaics. Dalton Transactions, 2025, 54(45): 16737-16744. https://doi.org/10.1039/D5DT01789K

(4) Zhihao Liu , Yong Zhao, Zhiqiang Zhang , Yongjia Li , Changlin Yao* , Junjie Wang , Zhengyan He , Rui Yang, Qi Zhang, Hai Zhong , Shufang Zhang*, Three-in-one synergistic effect of deprotonated molecules in enhancing perovskite solar cell performance and environmental safety. Materials Today Chemistry, 2025, 50: 103162. https://doi.org/10.1016/j.mtchem.2025.103162

(5) Zhiqiang Zhang, Yanpu Zheng, Changlin Yao*, Zhihao Liu, Xinyuan Wang, Zhengyan He, Guanying Xie, Hai Zhong, Qi Zhang, Shufang Zhang*,  Revealing the underlying crystallization mechanism of perovskite crystals affected by additives with a typical surfactant span 20. Journal of Alloys and Compounds, 2025, 1010: 177263. https://doi.org/10.1016/j.jallcom.2024.177263

(6) Jiaoyan Xu#; Changlin Yao#*; Shufang Zhang; Xiaodong Zou; Yue Gui; Lei Wang; Hongyi Xu ; Polyethylene Glycol-Assisted Melt Crystallization of Two New Piroxicam Polymorphs Revealed by 3D Electron Diffraction, Crystal Growth & Design, 2024, 24(17): 7298-7305. https://doi.org/10.1021/acs.cgd.4c00951

(7) Peizhuo Han; Lei Wang; Shuhong Song; Changlin Yao*; Xutang Tao; Guanying Xie; Huimin Li; Yaqian Qu; Hongshuai Wang; Zeliang Gao; Yanyan Sun; Huachang Wu; Weiguo Song ; Polymorphs and Solvates of Molnupiravir: Crystal Structures and Solid Forms Transformation Analysis, Crystal Growth & Design, 2024, 24(11): 4758-4769.https://doi.org/10.1021/acs.cgd.4c00376

(8) Kangning Sun; Peizhuo Han; Changlin Yao*; Yaning Zhao; Chuanchi Zhang; Yao Zhang; Jingke Jiang; Lei Wang ; Surface Accelerates Crystal Nucleation: The Case of Molnupiravir, Crystal Growth & Design, 2024, 24(15): 6413-6420. https://doi.org/10.1021/acs.cgd.4c00650

(9) Changlin Yao*; Shufang Zhang; Lei Wang; Xutang Tao; Recent Advances in Polymorph Discovery Methods of Organic Crystals, Crystal Growth & Design, 23, 2023, 637-654. https://doi.org/10.1021/acs.cgd.2c00960

(10) Changlin Yao; Lei Wang*; Xinyuan Wang; Xutang Tao*; Size-dependent solution-mediated phase transformation of piroxicam monohydrate particles, CrystEngComm, 2021, 23: 2928-2932. https://doi.org/10.1039/D1CE00237F

(11) Changlin Yao; Lei Wang; Yue Gui; Shigang Ruan; Ilia A. Guzei; Yingdi Jin; Guangxu Sun; Lian Yu ; Polymorphism of Piroxicam: New Polymorphs by Melt Crystallization and Crystal Structure Prediction, Crystal Growth & Design, 2020, 20(12): 7874-7881. https://doi.org/10.1021/acs.cgd.0c01165

(12) Changlin Yao; Yifan Li; Wang Lei; Shuang Song; Bo Li; Yang Liu; Xutang Tao. Tuning the Solution-Mediated Concomitant Phase Transformation Outcome of the Piroxicam Monohydrate by Two Hydroxyl-Containing Additives: Hydroxypropyl Cellulose and H₂O. Crystal Growth & Design. 2019, 19, 583-590. https://doi.org/10.1021/acs.cgd.8b00936

(13) 姚昌林，一种吡罗昔康新晶型及其制备方法和应用，ZL 2024 1 0324354.5，2025

近五年合作论文：

(1) Yaqian, Qu; Changlin Yao et al., Inhibition Efficiency of Cholesterol Monohydrate Crystallization by Linoleic Acid and Ethyl Linoleate. Cryst. Growth Des. 2025.

(2) Huimin Li; Lei Wang*; Xin Ye; Changlin Yao; Shuhong Song; Yaqian Qu; Jinke Jiang; Hongshuai Wang; Peizhuo Han; Yang Liu; Xutang Tao*, Efficient Screening of Pharmaceutical Cocrystals by Microspacing In-Air Sublimation, J. Am. Chem. Soc., 146, 2024, 11592-11598.

(3) Hongshuai Wang; Lei Wang*; Guanying Xie; Changlin Yao; Shuhong Song; Huimin Li; Yaqian Qu; Peizhuo Han; Zelaing Gao; Xutang Tao*, Solvates and Polymorphs of Baloxavir Marboxil: Crystal Structure and Phase Transformation Study, Cryst. Growth Des., 24, 2024, 3399-3409.

(4) Huimin Li; Lei Wang*; Guanying Xie; Changlin Yao; Shuhong Song; Yaqian Qu; Peizhuo Han; Hongshuai Wang; Yanyan Sun; Huachang Wu; Xutang Tao*, Cocrystals of Favipiravir: Improved Physicochemical Properties and Solution Stability Study, Cryst. Growth Des., 23, 2023, 8656-8669.

(5) Guanying Xie; Lei Wang; Dianxing Ju; Changlin Yao; Xinyuan Wang; Shuhong Song; Yaqian Qu; Huimin Li; Xutang Tao, Thermochromism Perovskite (COOH(CH2)3NH3)2PbI4 Crystals: Single-Crystal to Single-Crystal Phase Transition and Excitation-Wavelength-Dependent Emission. J. Phys. Chem. Lett. 2022, 13, 214-221.

(6) Guanying Xie; Lei Wang; Peizhou Li; Shuhong Song; Changlin Yao; Shanpeng Wang; Yang Liu; Zhen Wang; Xinyuan Wang; Xutang Tao, Low-Dimensional Hybrid Lead Iodide Perovskites Single Crystals via Bifunctional Amino Acid Cross-Linkage: Structural Diversity and Properties Controllability. ACS Appl. Mater. Interfaces. 2021, 13, 3325-3335.

(7) Xinyuan Wang; Lei Wang; Changlin Yao; Guanying Xie; Shuhong Song; Huimin Li; Yaqian Qu; Xutang Tao, Novel Formulations of the Antiviral Drug Favipiravir: Improving Permeability and Tabletability. Cryst. Growth Des. 2021, 21, 3807-3817.

(8) Shang Song; Lei Wang; Changlin Yao; Zhen Wang; Guanying Xie; Xutang Tao, Crystallization of Sulfathiazole in Gel: Polymorph Selectivity and Cross-Nucleation. Cryst. Growth Des. 2020, 20, 9-16.

(9) Zexin Wu; Lei Wang; Changlin Yao; Shang Song; Xinyuan Wang, Co-Amorphous Telmisartan-Pimelic Acid with Improved Solubility. Mater. Sci. Forum 2020, 993, 776-784.